Non-interpretable results during non-invasive prenatal testing (NIPT) have been occasionally associated with the incidental detection of occult maternal malignancies. Yet, no (inter)national orchestrated guidelines exist for the interpretation of such non-interpretable NIPT results. This is mainly due to the lack of prospective data that (a) inform about the identified genomic aberrations in the NIPT test while (b) providing (long-term) clinical follow-up data of women confronted with such NIPT results.
With our multicentric study “EU NIPT: Towards a better understanding of incidental cancer detection upon non-invasive prenatal testing” we want:
- To characterize the type of genomic aberrations in non-reportable NIPT results that are linked to a cancer (type).
- To investigate whether incidental identification of cancer via NIPT is associated with improved patient outcomes.
- To examine the occurrence of an incidental cancer diagnosis over the long term in cases with a non-reportable NIPT but for whom no underlying maternal malignancy was identified.
For further details on the preliminary research results check out our poster below.
If you are interested in participating, please read the protocol here and contact us at stefania.tuveri@kuleuven.be.
